Nanog fluctuations in ES cells highlight the problem of measurement in cell biology
نویسندگان
چکیده
Rosanna C G Smith,1 Patrick S Stumpf,1 Sonya J Ridden,2 Aaron Sim,3 Sarah Filippi,4 Heather Harrington,5 and Ben D MacArthur1, 2, 6, ∗ Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, SO17 1BJ, UK Mathematical Sciences, University of Southampton, SO17 1BJ, UK Department of Life Sciences, Imperial College London, SW7 2AZ, UK Department of Statistics, University of Oxford, OX1 3LB, UK Mathematical Institute, University of Oxford, OX2 6GG, UK Institute for Life Sciences, University of Southampton, SO17 1BJ, UK
منابع مشابه
Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.
A number of important pluripotency regulators, including the transcription factor Nanog, are observed to fluctuate stochastically in individual embryonic stem cells. By transiently priming cells for commitment to different lineages, these fluctuations are thought to be important to the maintenance of, and exit from, pluripotency. However, because temporal changes in intracellular protein abunda...
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There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using fluorescent reporters for the expression of Nanog, we observed that a population of ES cells is best described by a dynamic distribution of Nanog expression characterized by two peaks defined by high (HN) and l...
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